publications
View published articles from peer-reviewed journals
2021
Vibegron improves quality-of-life measures in patients with overactive bladder: patient-reported outcomes from the EMPOWUR study.
Int J Clin Pract. 2021;00:e13937. doi:10.1111/ijcp.13937
Efficacy and safety of once-daily vibegron for treatment of overactive bladder in patients aged ≥65 and ≥75 years: subpopulation analysis from the EMPOWUR randomized, international, phase III study.
Drugs Aging. Published online January 20,2021. doi:10.1007/s40266-020-00829-z
2020
Once-daily vibegron 75 mg for overactive bladder: long-term safety and efficacy from a double-blind extension study of the international phase 3 trial (EMPOWUR).
J Urol. Published online December 28, 2020. doi:10.1097/JU.0000000000001574
Vibegron 50 mg is the optimal algorithm in the pharmacologic management of overactive bladder: outcomes from a systematic review and meta-analysis.
Int Urol Nephrol. 2020;52(12):2215-2221. doi:10.1007/s11255-020-02536-5
Evaluating vibegron for the treatment of overactive bladder.
Expert Opin Pharmacother. 2020 Sep 29:1-9. [Epub ahead of print] doi:10.1080/14656566.2020.1809652
International phase III, randomized, double-blind, placebo and active controlled study to evaluate the safety and efficacy of vibegron in patients with symptoms of overactive bladder: EMPOWUR.
J Urol. 2020;204(2):316-324. doi:10.1097/JU.0000000000000807
Effects of vibegron, a novel β3-adrenoceptor agonist, and its combination with imidafenacin or silodosin in a rat with partial bladder outlet obstruction.
Eur J Pharmacol. Published online July 5, 2020. doi:10.1016/j.ejphar.2020.173096
The efficacy and safety of vibegron in treating overactive bladder: a systematic review and pooled analysis of randomized controlled trials.
Neurourol Urodyn. 2020;39(5):1255-1263. doi:10.1002/nau.24387
Efficacy of vibegron, a novel β3-adrenoreceptor agonist, on severe urgency urinary incontinence related to overactive bladder: post hoc analysis of a randomized, placebo-controlled, double-blind, comparative phase 3 study.
BJU Int. 2020;125(5):709-717. doi:10.1111/bju.15020
2019
Effects of the combination of vibegron and imidafenacin on bladder function in urethane-anesthetized rats.
Eur J Pharmacol. Published online December 1, 2019. doi:10.1016/j.ejphar.2019.172727
Vibegron (RVT-901/MK-4618/KRP-114V) administered once daily as monotherapy or concomitantly with tolterodine in patients with an overactive bladder: a multicenter, phase IIb, randomized, double-blind, controlled trial.
Eur Urol. 2019;75(2):274-282. doi:10.1016/j.eururo.2018.10.006
Efficacy of novel β3-adrenoreceptor agonist vibegron on nocturia in patients with overactive bladder: a post-hoc analysis of a randomized, double-blind, placebo-controlled phase 3 study.
Int J Urol. 2019;26(3):369-375. doi:10.1111/iju.13877
2018
Vibegron: first global approval.
Drugs. 2018;78(17):1835-1839. doi:10.1007/s40265-018-1006-3
Synthesis of vibegron enabled by a ketoreductase rationally designed for high pH dynamic kinetic reduction.
Angew Chem Int Ed Engl. 2018;57(23):6863-6867. doi:10.1002/anie.201802791
Vibegron, a novel potent and selective β3-adrenoreceptor agonist, for the treatment of patients with overactive bladder: a randomized, double-blind, placebo-controlled phase 3 study.
Eur Urol. 2018;73(5):783-790. doi:10.1016/j.eururo.2017.12.022
Long‐term safety and efficacy of the novel β3‐adrenoreceptor agonist vibegron in Japanese patients with overactive bladder: a phase III prospective study.
Int J Urol. 2018;25(7):668-675. doi:10.1111/iju.13596
2017
2D-QSAR and 3D-QSAR/CoMSIA studies on a series of (R)-2-((2-(1H-indol-2-yl)ethyl)amino)-1-phenylethan-1-ol with human β3-adrenergic activity.
Molecules. 2017;22(3):404. doi:10.3390/molecules2203040
Pharmacological characterization of a novel beta 3 adrenergic agonist, vibegron: evaluation of antimuscarinic receptor selectivity for combination therapy for overactive bladder.
J Pharmacol Exp Ther. 2017;360(2):346-355. doi:10.1124/jpet.116.237313
2016
Discovery of vibegron: a potent and selective β3-adrenergic receptor agonist for the treatment of overactive bladder.
J Med Chem. 2016;59(2):609-623. doi:10.1021/acs.jmedchem.5b01372
